CHAI-LING-TANG (JAPANESE NAME-SAIREI-TO) AS AN ORAL ADJUVANT

被引：8

作者：

EGAWA, Y

SUZUKI, I

NAGI, N

YADOMAE, T

KAWAKITA, T

KIKUCHI, S

NOMOTO, K

机构：

[1] TOKYO COLL PHARM,IMMUNOPHARMACOL MICROBIAL PROD LAB,HORINOUCHI 1432-1,HACHIOJI,TOKYO 19203,JAPAN

[2] KANEBO CO LTD,KAMPO RES LABS,MIYAKOJIMA KU,OSAKA 534,JAPAN

[3] KYUSHU UNIV,MED INST BIOREGULAT,DEPT IMMUNOL,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1991年 / 13卷 / 07期

关键词：

D O I：

10.1016/0192-0561(91)90058-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunomodulating and anti-tumor activities of orally administered Chai-Ling-Tang (Japanese name: sairei-to, ST) were investigated. The oral administration of ST into mice augmented the antibody response to intraperitoneally administered 2, 4, 6-trinitrophenyl-haptenated sheep red blood cells (TNP-SRBC). Orally administered ST showed also an enhancing effect on the antibody response to TNP-SRBC administered by the oral route. In addition, orally administered ST markedly activated the peritoneal macrophages to enhanced phagocytic and lysosomal enzyme activities. A significant inhibition of tumor growth was observed in a syngeneic tumor - mouse system when ST was administered orally. These results suggest that ST has an efficiency as an oral adjuvant or an oral biological response modifier (BRM).

引用

页码：1031 / 1036

页数：6

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