NEW IMMUNOSUPPRESSIVE DRUGS - NEEDS IN AND APPLICATIONS TO PEDIATRIC TRANSPLANTATION

被引：5

作者：

KAHAN, BD

机构：

[1] Division of Immunology and Organ Transplant, Department of Surgery, The University of Texas Medical School at Houston, Houston, 77030, TX, 6431 Fannin

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1992年 / 151卷

关键词：

IMMUNOSUPPRESSION; DRUG INTERACTIONS; CYCLOSPORINE;

D O I：

10.1007/BF02125796

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The evolution of immunosuppressive therapy toward synergistic drug combinations seeks to minimize toxicity while potentiating efficacy. Median effect analysis discerns synergistic drug combinations that may be suitable for in vivo experiments in animals and for subsequent clinical trials. These studies suggest that two drugs rapamycin (RAPA) and brequinar (BQR) display synergistic effects in combination with cyclosporine. This combination must be evaluated for relative toxicity versus efficacy. Clinical trials to assess the individual toxicities of RAPA and BQR are presently underway in order to discern appropriate doses for randomized trials of clinical efficacy.

引用

页码：S9 / S12

页数：4

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