COUPLING OF ANTIVIRAL NUCLEOSIDE ANALOGS TO LACTOSAMINATED HUMAN ALBUMIN BY USING THE IMIDAZOLIDES OF THEIR PHOSPHORIC ESTERS

被引：22

作者：

FIUME, L

BUSI, C

DISTEFANO, G

MATTIOLI, A

机构：

[1] Department of Experimental Pathology, University of Bologna, 40126 Bologna

来源：

ANALYTICAL BIOCHEMISTRY | 1993年 / 212卷 / 02期

关键词：

D O I：

10.1006/abio.1993.1348

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver targeting of antiviral nucleoside analogs can be obtained by conjugating these drugs with the hepatotropic molecule lactosaminated serum albumin. We describe a new coupling procedure which uses the imidazolides of the phosphoric ester derivatives of the drugs in an alkaline medium. By this procedure conjugates are obtained with a high drug/carrier molar ratio and without the unwanted protein chemical changes produced by carbodiimides usually employed for this coupling. © 1994 Academic Press, Inc. All rights reserved.

引用

页码：407 / 411

页数：5

共 26 条

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Ames BN., 1966, METHOD ENZYMOL, V8, P115, DOI DOI 10.1016/0076-6879(66)08014-5

[2] CARBOHYDRATE-SPECIFIC RECEPTORS OF THE LIVER [J].