COORDINATION OF CHIRAL AMINES TO COORDINATIVELY UNSATURATED CP-ASTERISK-IR-AMINO ACID COMPLEXES ALLOWS DETERMINATION OF ENANTIOMERIC PURITY

被引：37

作者：

GROTJAHN, DB

JOUBRAN, C

机构：

[1] Department of Chemistry and Biochemistry, Arizona State University Tempe, AZ 85287-1604

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1016/0957-4166(95)00070-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Coordinatively unsaturated complexes of the Cp*Ir fragment to the dianion of N-tosylamino acids combine with chiral amines in a highly diastereoselective fashion, such that metallacycle substituents R (amino acid side chain) and Cp* are cis. Observation of adducts between the alanine- and phenylglycine-derived complexes and (S)-alpha-methylbenzylamine by NMR at low to ambient temperature allows determination of the enantiomeric purity of either component, 1 to 2% impurity being easily detectable. Furthermore, alpha-methylbenzylamine was analyzed for its enantiomeric purity independent of external chiral reagent, by its conversion to N,N'-bis(1-phenylethyl)urea.

引用

页码：745 / 752

页数：8

共 31 条

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Allenmark S. G., 1988, CHROMATOGRAPHIC ENAN

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