BRANCHED OLIGODEOXYNUCLEOTIDES - A NEW SYNTHETIC STRATEGY AND FORMATION OF STRONG INTRAMOLECULAR AND INTERMOLECULAR TRIPLE-HELICAL COMPLEXES

被引：12

作者：

BRANDENBURG, G ^{[1
]}

PETERSEN, GV ^{[1
]}

RASMUSSEN, K ^{[1
]}

WENGEL, J ^{[1
]}

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00114-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A fully automated synthetic strategy for preparation of branched oligodeoxynucleotide (ODN) analogues with sequences of arbitrary length and base composition is described. Various novel triple helix forming branched ODNs were synthesized and their behavior during thermal denaturation at 260 nm and 284 nm studied. The intra- and intermolecular hybridization properties of the novel branched ODNs are improved compared to analogous linear ODNs.

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页码：791 / 794

页数：4

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