IMMUNOTOXICOLOGY OF BROWN RECLUSE SPIDER (LOXOSCELES-RECLUSA) VENOM

被引：16

作者：

BABCOCK, JL ^{[1
]}

MARMER, DJ ^{[1
]}

STEELE, RW ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI, DEPT PEDIAT, IMMUNOL & INFECT DIS SECT, LITTLE ROCK, AR 72205 USA

来源：

TOXICON | 1986年 / 24卷 / 08期

关键词：

D O I：

10.1016/0041-0101(86)90103-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A purified toxin protein from Loxosceles reclusa venom was assayed for its in vitro effects on the human immunological and blood clotting systems. The toxin caused inhibition of neutrophil chemotaxis, depletion of serum hemolytic complement, prolongation of the activated partial thromboplastin time and depletion of clotting factors XII, XI, IX and VIII by an average of 44% in human plasma. The prothrombin time of human plasma was also prolonged by 1.5-2.0 sec. No effect of the purified toxin was observed on microbicidal abilty of neutrophils, the release of enzymes from the neutrophils or the adherence of neurtrophils to glass beads.

引用

页码：783 / 790

页数：8

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