STRUCTURE OF CROTEPOXIDE - X-RAY ANALYSIS OF CROTEPOXIDE LODOHYDRIN

X-Ray crystal-structure analysis of crotepoxide iodohydrin has defined the constitution and absolute stereochemistry of crotepoxide, a novel tumour-inhibiting cyclohexane diepoxide derivative isolated from Croton macrostachys. Crystals of the iodohydrin are monoclinic. space groupP2 1, with Z = 2, and unit-cell dimensions a = 5.21, b = 15.85, c = 12.18 Å, β = 100° 42′. The atomic co-ordinates were determined by Fourier and least-squares calculations, and the final value of R was 12.2% for 1166 independent reflexions. The cyclohexene oxide ring displays a half-chair conformation.