PROTECTIVE EFFECTS OF A NOVEL THROMBOXANE ANALOG IN LETHAL TRAUMATIC SHOCK

被引：33

作者：

LEFER, AM

ARAKI, H

SMITH, JB

NICOLAOU, KC

MAGOLDA, RL

机构：

[1] Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia

来源：

PROSTAGLANDINS AND MEDICINE | 1979年 / 3卷 / 03期

关键词：

D O I：

10.1016/0161-4630(79)90097-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 umole·kg-1·h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood. © 1979.

引用

页码：139 / 145

页数：7

共 22 条

[1] ANSON ML, 1936, J GEN PHYSIOL, V20, P565
[2] MECHANISMS OF PRODUCTION OF CIRCULATORY SHOCK FACTORS IN ISOLATED PERFUSED PANCREAS
FERGUSON, WW
LEFER, AM
GLENN, TM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1972, 222 (02): : 450 - +
[3] FERRARIS V, 1977, THROMB HAEMOSTASIS, V38, P20
[4] GALVIN MJ, EXPERIENTIA
[5] SIGNIFICANCE OF SPLANCHNIC PROTEASES IN PRODUCTION OF A TOXIC FACTOR IN HEMORRHAGIC SHOCK
GLENN, TM
LEFER, AM
[J]. CIRCULATION RESEARCH, 1971, 29 (04) : 338 - +
[6] GORNALL AG, 1949, J BIOL CHEM, V177, P751
[7] HAMBERG M, 1975, P NATL ACAD SCI USA, V72, P2991
[8] PANCREATIC HYDROLASES AND FORMATION OF A MYOCARDIAL DEPRESSANT FACTOR IN SHOCK
LEFER, AM
BARENHOLZ, Y
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1972, 223 (05): : 1103 - +
[9] PANCREATIC HYPOPERFUSION AND PRODUCTION OF A MYOCARDIAL DEPRESSANT FACTOR IN HEMORRHAGIC-SHOCK
LEFER, AM
SPATH, JA
[J]. ANNALS OF SURGERY, 1974, 179 (06) : 868 - 876
[10] MYOCARDIAL DEPRESSANT FACTOR AND CIRCULATORY SHOCK
LEFER, AM
[J]. KLINISCHE WOCHENSCHRIFT, 1974, 52 (08): : 358 - 370

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