FATE DURING CELL-GROWTH OF YEAST MITOCHONDRIAL AND NUCLEAR-DNA AFTER PHOTOLYTIC ATTACHMENT OF THE MONOAZIDE ANALOG OF ETHIDIUM

被引：32

作者：

FUKUNAGA, M ^{[1
]}

YIELDING, KL ^{[1
]}

机构：

[1] UNIV ALABAMA, MOLEC BIOL LAB, BIRMINGHAM, AL 35294 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91275-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 14C-labeled photosensitive monazide analog of ethidium, 3-amino-8-azido-5-ethyl-6-phenylphenanthridinium chloride, produced covalent adducts in yeast cells with both nuclear and mitochondrial DNA on photolysis by visible light. With subsequent cultivation in nutrient medium, drug molecules on mitochondrial DNA were removed only through extensive mitochondrial DNA degradation. In contrast, drug attached to nuclear DNA was eliminated with conservation of DNA, presumably through a repair process.

引用

页码：582 / 586

页数：5

共 15 条

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