ETIOLOGY OF CEREBRAL VASOSPASM IN PRIMATES

被引:125
作者
MACDONALD, RL
WEIR, BKA
RUNZER, TD
GRACE, MGA
FINDLAY, JM
SAITO, K
COOK, DA
MIELKE, BW
KANAMARU, K
机构
[1] UNIV ALBERTA,DEPT PATHOL,EDMONTON T6G 2B7,ALBERTA,CANADA
[2] UNIV ALBERTA,DEPT PHARMACOL,EDMONTON T6G 2B7,ALBERTA,CANADA
[3] UNIV ALBERTA,DIV NEUROSURG,EDMONTON T6G 2B7,ALBERTA,CANADA
关键词
BILIRUBIN; ANEURYSM; METHEMOGLOBIN; OXYHEMOGLOBIN; SUBARACHNOID HEMORRHAGE; VASOSPASM; CYNOMOLGUS MONKEY;
D O I
10.3171/jns.1991.75.3.0415
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A primate model was used to determine whether oxyhemoglobin (OxyHb), methemoglobin (MetHb), or bilirubin is likely to be responsible for cerebral vasospasm following subarachnoid hemorrhage (SAH). Forty cynomolgus monkeys were randomly assigned to one of five groups. On Day 0, each animal underwent angiography followed by right craniectomy and placement of an Ommaya reservoir with its catheter adjacent to the right middle cerebral artery (MCA). The animals received intrathecal injections twice a day for 6 days of one of the following solutions: mock cerebrospinal fluid (CSF); OxyHb; MetHb; bilirubin; or supernatant fluid from an incubated mixture of autologous blood and mock CSF. On Day 7, angiography was repeated and the animals were killed. Comparison of angiograms obtained on Day 0 and Day 7 of the experiment showed significant vasospasm of the right MCA and the right anterior cerebral and internal carotid arteries in the animal groups that had received OxyHb or supernatant fluid. There was a smaller reduction in diameter of the same vessels in the bilirubin group (not statistically significant), while no effects were observed in the groups receiving MetHb or mock CSF. Electron microscopy of the right MCA's gave results consistent with the angiographic findings. One monkey in the OxyHb group developed a delayed-onset right MCA infarction. These data suggest that OxyHb is the cause of cerebral vasospasm following SAH.
引用
收藏
页码:415 / 424
页数:10
相关论文
共 34 条
[1]  
Asano T, 1980, CEREBRAL ARTERIAL SP, P190
[2]   THE NATURE AND CLINICAL SIGNIFICANCE OF PIGMENTS IN THE CEREBROSPINAL FLUID [J].
BARROWS, LJ ;
HUNTER, FT ;
BANKER, BQ .
BRAIN, 1955, 78 (01) :59-80
[3]   THE ROLE OF HEMOGLOBIN IN THE ETIOLOGY OF CEREBRAL VASOSPASM - AN INVIVO STUDY OF BABOONS [J].
BOULLIN, DJ ;
TAGARI, P ;
DUBOULAY, G ;
AITKEN, V ;
HUGHES, JT .
JOURNAL OF NEUROSURGERY, 1983, 59 (02) :231-236
[4]  
CHOKYU M, 1975, OSAKA CITY MED J, V24, P211
[5]  
COOK DA, 1979, P W PHARMACOL SOC, V22, P429
[6]   ERYTHROCYTES ARE ESSENTIAL FOR DEVELOPMENT OF CEREBRAL VASCULOPATHY RESULTING FROM SUBARACHNOID HEMORRHAGE IN CATS [J].
DUFF, TA ;
LOUIE, J ;
FEILBACH, JA ;
SCOTT, G .
STROKE, 1988, 19 (01) :68-72
[7]   BILIRUBIN AND THE INDUCTION OF INTRACRANIAL ARTERIAL SPASM [J].
DUFF, TA ;
FEILBACH, JA ;
YUSUF, Q ;
SCOTT, G .
JOURNAL OF NEUROSURGERY, 1988, 69 (04) :593-598
[8]   PHYSIOLOGICAL SALT SOLUTIONS FOR BRAIN SURGERY - STUDIES OF LOCAL PH AND PIAL VESSEL REACTIONS TO BUFFERED AND UNBUFFERED ISOTONIC SOLUTIONS [J].
ELLIOTT, KAC ;
JASPER, HH .
JOURNAL OF NEUROSURGERY, 1949, 6 (02) :140-152
[9]  
Endo S, 1977, Neurol Med Chir (Tokyo), V17 Pt. 2, P313, DOI 10.2176/nmc.17pt2.313
[10]   EFFECT OF INTRATHECAL THROMBOLYTIC THERAPY ON SUBARACHNOID CLOT AND CHRONIC VASOSPASM IN A PRIMATE MODEL OF SAH [J].
FINDLAY, JM ;
WEIR, BKA ;
STEINKE, D ;
TANABE, T ;
GORDON, P ;
GRACE, M .
JOURNAL OF NEUROSURGERY, 1988, 69 (05) :723-735