ACTIVIN-A INDUCED EXPRESSION OF A FORK-HEAD RELATED GENE IN POSTERIOR CHORDAMESODERM (NOTOCHORD) OF XENOPUS-LAEVIS EMBRYOS

被引:117
作者
KNOCHEL, S [1 ]
LEF, J [1 ]
CLEMENT, J [1 ]
KLOCKE, B [1 ]
HILLE, S [1 ]
KOSTER, M [1 ]
KNOCHEL, W [1 ]
机构
[1] UNIV ULM,BIOCHEM ABT,OBERER ESELSBERG,W-7900 ULM,GERMANY
关键词
FORK-HEAD DOMAIN; TRANSCRIPTION FACTOR; DORSAL BLASTOPORE LIP; MESODERM INDUCTION; XENOPUS-LAEVIS;
D O I
10.1016/0925-4773(92)90007-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A gene family encoding the fork head / HNF-3 domain has been identified in the South African clawed frog, Xenopus laevis. Screening of genomic DNA and gastrula stage derived CDNA libraries with a DNA fragment encoding the Drosophila fork head domain led to the isolation of a number of different clones encoding this motif. While one of the Xenopus fork head sequences, XFD-3, represents the Xenopus counterpart to rat HNF-3-beta, all other sequences encode novel types of fork head related proteins. Here we report on XFD-1, a DNA binding protein which can bind to the HNF-3-alpha target sequence. Analysis of temporal and spatial expression revealed that the gene is activated at blastula stage and that transcripts are localized in a rather thin stripe of cells invaginating the dorsal blastopore lip (organizer) during gastrulation. XFD-1 mRNA is localized within the notochord and, by the end of neurulation, is no longer detectable. In the animal cap assay the gene is activated by incubation with the vegetalizing factor (activin A) but not with bFGF.
引用
收藏
页码:157 / 165
页数:9
相关论文
共 31 条
[1]   MESODERMAL INDUCTION IN EARLY AMPHIBIAN EMBRYOS BY ACTIVIN-A (ERYTHROID-DIFFERENTIATION FACTOR) [J].
ASASHIMA, M ;
NAKANO, H ;
SHIMADA, K ;
KINOSHITA, K ;
ISHII, K ;
SHIBAI, H ;
UENO, N .
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1990, 198 (06) :330-335
[2]   ALBUMIN PHYLOGENY FOR CLAWED FROGS (XENOPUS) [J].
BISBEE, CA ;
BAKER, MA ;
WILSON, AC ;
HADJIAZIMI, I ;
FISCHBERG, M .
SCIENCE, 1977, 195 (4280) :785-787
[3]   MOLECULAR NATURE OF SPEMANNS ORGANIZER - THE ROLE OF THE XENOPUS HOMEOBOX GENE GOOSECOID [J].
CHO, KWY ;
BLUMBERG, B ;
STEINBEISSER, H ;
DEROBERTIS, EM .
CELL, 1991, 67 (06) :1111-1120
[4]  
EIJNDENVANRAAIJ AJ, 1990, NATURE, V345, P732
[5]  
GREEN JBA, 1990, NATURE, V347, P391, DOI 10.1038/347391a0
[6]  
HARLAND RM, 1991, METHOD CELL BIOL, V36, P685
[7]  
HEMMATIBRIVANLOU A, 1990, DEVELOPMENT, V110, P325
[8]   DIFFUSIBLE FACTORS IN VERTEBRATE EMBRYONIC INDUCTION [J].
JESSELL, TM ;
MELTON, DA .
CELL, 1992, 68 (02) :257-270
[9]   TERMINAL VERSUS SEGMENTAL DEVELOPMENT IN THE DROSOPHILA EMBRYO - THE ROLE OF THE HOMEOTIC GENE FORK HEAD [J].
JURGENS, G ;
WEIGEL, D .
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1988, 197 (06) :345-354
[10]   EMBRYONIC INDUCERS, GROWTH-FACTORS, TRANSCRIPTION FACTORS AND ONCOGENES [J].
KNOCHEL, W ;
TIEDEMANN, H .
CELL DIFFERENTIATION AND DEVELOPMENT, 1989, 26 (03) :163-171