Motor neurons in the embryonic chick spinal cord express a homeobox gene, islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.
机构:
FAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCEFAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCE
DUBOULE, D
DOLLE, P
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机构:
FAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCEFAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCE
机构:
FAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCEFAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCE
DUBOULE, D
DOLLE, P
论文数: 0引用数: 0
h-index: 0
机构:
FAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCEFAC MED STRASBOURG,GENET MOLEC EUCARYOTES LAB,CNRS,U184,INSERM,F-67085 STRASBOURG,FRANCE