EARLY STAGES OF MOTOR-NEURON DIFFERENTIATION REVEALED BY EXPRESSION OF HOMEOBOX GENE ISLET-1

被引:576
作者
ERICSON, J
THOR, S
EDLUND, T
JESSELL, TM
YAMADA, T
机构
[1] COLUMBIA UNIV, HAMMER HLTH SCI CTR, CTR NEUROBIOL & BEHAV, HOWARD HUGHES MED INST, NEW YORK, NY 10032 USA
[2] UMEA UNIV, DEPT MICROBIOL, S-90187 UMEA, SWEDEN
关键词
D O I
10.1126/science.1350865
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Motor neurons in the embryonic chick spinal cord express a homeobox gene, islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.
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页码:1555 / 1560
页数:6
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