A POSTSYNAPTIC GABA TRANSPORTER IN RAT SPINAL MOTOR NEURONS

被引：19

作者：

SNOW, H ^{[1
]}

LOWRIE, MB ^{[1
]}

BENNETT, JP ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,IMPERIAL COLL,DEPT ANAT & CELL BIOL,NORFOLK PL,LONDON W2 1PG,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

基金：

英国惠康基金;

关键词：

SPINAL CORD; MOTONEURON; INSITU HYBRIDIZATION; NEUROTRANSMITTER UPTAKE; GLUTAMIC ACID DECARBOXYLASE; CHOLINE ACETYL TRANSFERASE; GAMMA-AMINOBUTYRIC ACID TRANSPORTER GAT-1;

D O I：

10.1016/0304-3940(92)90246-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The plasma membrane uptake system for gamma-amino butyric acid (GABA) is conventionally assumed to be presynaptic, so that after release GABA could be taken up and incorporated into synaptic vesicles for re-use. Using in situ hybridization histochemistry we find that rat spinal motor neurones express GAT-1, a transporter protein for GABA, but that they do not express glutamic acid decarboxylase, the synthetic enzyme for GABA. We conclude that the uptake system is located postsynaptically in these cells. Our observation may explain previous reports where GABA has been detected immunocytochemically in motor neurones.

引用

页码：119 / 122

页数：4

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