FUNCTIONAL-SIGNIFICANCE OF MESOLIMBIC DOPAMINE

被引:109
作者
KIYATKIN, EA
机构
[1] Program in Neural Science, Indiana University, Bloomington, IN 47405, Psychology Building
关键词
GOAL-DIRECTED BEHAVIOR; ELECTROCHEMISTRY; ELECTROPHYSIOLOGY; NUCLEUS ACCUMBENS; HEROIN; COCAINE; FEEDING; MOTIVATION; REINFORCEMENT;
D O I
10.1016/0149-7634(95)00029-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Although a large body of neuropharmacological evidence suggests that the mesolimbic dopamine system (ML DA) is critical for goal-directed behaviors, exactly which aspects of behavior are mediated or modulated by this system remains a matter of conjecture. By measuring changes in DA cell firing patterns and extracellular DA concentrations in target areas of ML DA cells during the development and performance of goal-directed behavior, it is possible to directly examine the relationship between ML DA transmission and various stages and components of behavior. This permits tests of hypotheses concerned with the functional significance of ML DA. This review will discuss recent electrophysiological, microdialysis and electrochemical data on behavior-associated changes in firing activity of ML DA cells and fluctuations in DA concentrations in target areas of these cells. Although application of an electrochemical technique to study behavior-associated changes in DA transmission is an area of hot debates, a close correlation between DA-dependent electrochemical signal changes and separate behavioral components, with a generally similar pattern of rapid signal fluctuations found in trained animals during operant lever-pressing behavior maintained by palatable food, cocaine or heroin, suggests that extrasynaptic DA may have some important functions in regulating behavior. This review will discuss possible mechanisms underlying phasic and tonic changes in ML DA transmission accompanying development and performance of positively-reinforced behavior, the contribution of learning, behavioral and pharmacological variables in the mediation of these changes, and their relevance for the organization and regulation of goal-directed behavior.
引用
收藏
页码:573 / 598
页数:26
相关论文
共 187 条
[1]   DOPAMINERGIC MODULATION OF SENSORY RESPONSES OF STRIATAL NEURONS - SINGLE UNIT STUDIES [J].
ABERCROMBIE, E ;
JACOBS, BL .
BRAIN RESEARCH, 1985, 358 (1-2) :27-33
[2]   DIFFERENTIAL EFFECT OF STRESS ON INVIVO DOPAMINE RELEASE IN STRIATUM, NUCLEUS ACCUMBENS, AND MEDIAL FRONTAL-CORTEX [J].
ABERCROMBIE, ED ;
KEEFE, KA ;
DIFRISCHIA, DS ;
ZIGMOND, MJ .
JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) :1655-1658
[3]   INVIVO ELECTROCHEMICAL MEASUREMENTS IN THE CNS [J].
ADAMS, RN .
PROGRESS IN NEUROBIOLOGY, 1990, 35 (04) :297-311
[4]   DOPAMINE AUTORECEPTORS - PHARMACOLOGICAL CHARACTERIZATION BY MICROIONTOPHORETIC SINGLE CELL RECORDING STUDIES [J].
AGHAJANIAN, GK ;
BUNNEY, BS .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1977, 297 (01) :1-7
[5]  
AKAIKE A, 1984, J PHARMACOL EXP THER, V229, P859
[6]  
ANTELMAN SM, 1984, HDB PSYCHOPHARMACOLO, P279
[7]   BRAIN MICRODIALYSIS [J].
BENVENISTE, H .
JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1667-1679
[8]  
Berger TW, 1987, NEUROPHYSIOLOGY DOPA, P253
[9]   DOPAMINE ATTENUATES THE EFFECTS OF GABA ON SINGLE UNIT-ACTIVITY IN THE GLOBUS PALLIDUS [J].
BERGSTROM, DA ;
WALTERS, JR .
BRAIN RESEARCH, 1984, 310 (01) :23-33
[10]   DOPAMINE IN DENDRITES OF SUBSTANTIA NIGRA NEURONS - SUGGESTIONS FOR A ROLE IN DENDRITIC TERMINALS [J].
BJORKLUND, A ;
LINDVALL, O .
BRAIN RESEARCH, 1975, 83 (03) :531-537