CORTICOTROPIN-RELEASING FACTOR TREATMENT UP-REGULATES INTERLEUKIN-1 RECEPTORS IN THE MOUSE PITUITARY - REVERSAL BY DEXAMETHASONE

被引：11

作者：

TAKAO, T ^{[1
]}

TOJO, C ^{[1
]}

NISHIOKA, T ^{[1
]}

HASHIMOTO, K ^{[1
]}

DESOUZA, EB ^{[1
]}

机构：

[1] NEUROCRINE BIOSCI INC,SAN DIEGO,CA 92121

来源：

BRAIN RESEARCH | 1995年 / 688卷 / 1-2期

关键词：

ACTH; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; IL-1; RECEPTOR; PITUITARY; STRESS;

D O I：

10.1016/0006-8993(95)00561-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraperitoneal injection of rat/human corticotropin-releasing factor (CRF) (40 mu g/kg/0.2 ml of saline) resulted in a dramatic increase in specific iodine-125-labeled human interleukin-1 alpha ([I-125]IL-1 alpha) binding in the male C57BL/6 mouse pituitary at 2 and 6 h after the injection although it did not affect [I-125]IL-1 alpha binding in the mouse hippocampus, spleen and testis at any time after the injection. [I-125]IL-1 alpha binding was unchanged at 2 h following dexamethasone (DEX) treatment (1 mg/kg/0.2 ml of 4% ethanol-saline) in the mouse pituitary and the hippocampus. in contrast, DEX inhibited CRF-induced upregulation of IL-1 receptors in the pituitary at 2 h after the injection. These data demonstrate complex interactions between CRF and DEX on IL-1 receptors during stress.

引用

页码：219 / 222

页数：4

共 26 条

[1] REGULATION OF INTERLEUKIN-1 RECEPTOR EXPRESSION IN MOUSE-BRAIN AND PITUITARY BY LIPOPOLYSACCHARIDE AND GLUCOCORTICOIDS [J].