CD-44 EXON V6 AS A PREDICTOR OF LYMPHATIC METASTASES IN CERVICAL-CARCINOMA - AN IMMUNOCYTOCHEMICAL STUDY OF 94 CASES

被引：17

作者：

BIESOLD, C

KOHLER, U

HORN, LC

BILEK, K

KADE, R

EMMERT, C

机构：

[1] UNIV LEIPZIG,DEPT GYNECOL & OBSTET,D-04103 LEIPZIG,GERMANY

[2] UNIV LEIPZIG,DEPT PATHOL,D-04103 LEIPZIG,GERMANY

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 1995年 / 256卷 / 03期

关键词：

CERVICAL CARCINOMA; TUMOR MARKER; CD; 44; METASTASES;

D O I：

10.1007/s004040050083

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The relation between expression of several splicing variants of the CD 44 glycoprotein by tumor cells and the increased risk of metastases was discussed recently. By means of an immunocytochemical study (imprint cytology specimens from 94 invasive cervical carcinomas) we have shown a significant correlation between expression of CD 44 v6 and invasion of lymphatic vessels, lymphangiosis carcinomatosa in the primary tumor and the total number of positive pelvic lymph nodes. Expression of CD 44 v6 was not correlated with staging, grading and histological type. CD 44 v6 could therefore be considered as a predictor of lymphatic metastases in cervical carcinoma.

引用

页码：147 / 153

页数：7

共 23 条

[1] PARTICIPATION IN NORMAL IMMUNE-RESPONSES OF A METASTASIS-INDUCING SPLICE VARIANT OF CD44 [J].

ARCH, R ;

WIRTH, K ;

HOFMANN, M ;

PONTA, H ;

MATZKU, S ;

HERRLICH, P ;

ZOLLER, M .

SCIENCE, 1992, 257 (5070) :682-685

[2] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].

ARUFFO, A ;

STAMENKOVIC, I ;

MELNICK, M ;

UNDERHILL, CB ;

SEED, B .

CELL, 1990, 61 (07) :1303-1313

[3]

DALL P, 1994, CANCER RES, V54, P3337

[4]

DENNING SM, 1990, J IMMUNOL, V144, P7

[5] CD44 AND CANCER SCREENING [J].

FOX, SB ;

GATTER, KC ;

JACKSON, DG ;

SCREATON, GR ;

BELL, MV ;

BELL, JI ;

HARRIS, AL ;

SIMMONS, D ;

FAWCETT, J .

LANCET, 1993, 342 (8870) :548-549

[6]

HEKELE A, 1994, ARCH GYNECOL OBST S1, V255, P181

[7] CD44 SPLICE VARIANTS - METASTASES MEET LYMPHOCYTES [J].

HERRLICH, P ;

ZOLLER, M ;

PALS, ST ;

PONTA, H .

IMMUNOLOGY TODAY, 1993, 14 (08) :395-399

[8]

HERRLICH P, 1994, IN PRESS CELL ADHESI

[9]

HUET S, 1989, J IMMUNOL, V143, P798

[10] LYMPHOCYTE CD44 BINDS THE COOH-TERMINAL HEPARIN-BINDING DOMAIN OF FIBRONECTIN [J].

JALKANEN, S ;

JALKANEN, M .

JOURNAL OF CELL BIOLOGY, 1992, 116 (03) :817-825

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