PULVOMYCIN, AN INHIBITOR OF PROKARYOTIC PROTEIN-BIOSYNTHESIS

被引：10

作者：

ASSMANN, D ^{[1
]}

WOLF, H ^{[1
]}

机构：

[1] UNIV TUBINGEN,LEHRBEREICH MIKROBIOL 1,INST BIOL 2,D-7400 TUBINGEN 1,FED REP GER

来源：

ARCHIVES OF MICROBIOLOGY | 1979年 / 120卷 / 03期

关键词：

Antibiotics from Actinomycetales; Labilomycin; Protein biosynthesis; Pulvomycin;

D O I：

10.1007/BF00423079

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotic 1063-Z isolated from culture fluids of Streptoverticillium mobaraense was identified as pulvomycin. Pulvomycin was observed to inhibit protein biosynthesis in growing cells of Bacillus brevis. The poly(U)-directed poly(Phe) synthesis in cell-free systems of Bacillus brevis and Escherichia coli was highly susceptible to the antibiotic. Pulvomycin did not affect the transfer of Phe to tRNA. The results suggest that the target of pulvomycin action is the polypeptide chain elongation. © 1979 Springer-Verlag.

引用

页码：297 / 299

页数：3

共 9 条

[1]

AKITA E, 1963, J ANTIBIOT, V16, P147

[2]

EIKHOM TS, 1963, BIOCHIM BIOPHYS ACTA, V76, P465

[3] ISOLATION AND CHARACTERIZATION OF RIBONUCLEASE I MUTANTS OF ESCHERICHIA COLI [J].

GESTELAND, RF .

JOURNAL OF MOLECULAR BIOLOGY, 1966, 16 (01) :67-+

[4]

KELMERS AD, 1966, J BIOL CHEM, V241, P3540

[5]

LOCCI R, 1969, GIORN MICROBIOL, V17, P1

[6] IDENTIFICATION OF MYCOLUTEIN AND PULVOMYCIN AS AUREOTHIN AND LABILOMYCIN RESPECTIVELY [J].

SCHWARTZ, JL ;

TISHLER, M ;

ARISON, BH ;

SHAFER, HM ;

OMURA, S .

JOURNAL OF ANTIBIOTICS, 1976, 29 (03) :236-241

[7]

STAEHELIN T, 1971, METHODS ENZYMOLOGY C, V20, P449

[8]

Traub P, 1971, METHOD ENZYMOL, V20, P391

[9]

ZIEF M, 1957, PULVOMYCIN ANTIBIOT, V7, P384

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