KETAMINE PROMOTES HIPPOCAMPAL CA1 PYRAMIDAL NEURON LOSS AFTER A SHORT-DURATION ISCHEMIC INSULT IN RATS

被引：11

作者：

CHURCH, J ^{[1
]}

ZEMAN, S ^{[1
]}

机构：

[1] UNIV LONDON ROYAL VET COLL,DEPT VET BASIC SCI,LONDON NW1 0TU,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 123卷 / 01期

基金：

英国惠康基金;

关键词：

KETAMINE; N-METHYL-D-ASPARTATE RECEPTOR; HIPPOCAMPUS; NEUROPROTECTION;

D O I：

10.1016/0304-3940(91)90159-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroprotective activity of the N-methyl-D-aspartate (NMDA) antagonist ketamine was examined in two groups of rats subjected to forebrain ischemia of differing durations. Ketamine provided a limited degree of protection against hippocampal CA1 pyramidal cell loss following a 10 min ischemic insult. In contrast after 6 min ischemia, which in non-treated control animals resulted in less CA1 neuron loss than was seen after 10 min ischemia, ketamine at the same dose worsened outcome. The data indicate that the possession by a drug of NMDA antagonist activity does not alone determine its neuroprotective activity in vivo.

引用

页码：65 / 68

页数：4

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