EXPRESSION OF THE HUMAN V-BETA-8 GENE-PRODUCT PREFERENTIALLY CORRELATES WITH CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION SPECIFICITY

被引：25

作者：

IMBERTI, L

SOTTINI, A

SPAGNOLI, G

PRIMI, D

机构：

[1] CNR,CONSORZIO BIOTECNOL,BIOTECNOL LAB,P SPEDALI CIVILI 1,I-25123 BRESCIA,ITALY

[2] CNR,SCH MED,INST CHEM,INST TIPIZZAZ TISSUTALE & PROBLEMI DIALISI,ROME,ITALY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 12期

关键词：

D O I：

10.1002/eji.1830201244

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report that, in peripheral blood T cells, the V-beta-8 gene product is much more represented on CD4+CD8- than on CD4-CD8+ lymphocytes. This skewing was observed in all individuals tested and with two independent strategies, one of which allows the selection of V-beta-8+ T cells independently from their major histocompatibility complex-antigen specificity. Our data imply that the human V-beta-8 gene product confers class II restriction specificity and that both the T cell receptor chains and CD4 molecule are involved in the selection of the T cell repertoire.

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页码：2817 / 2819

页数：3

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