GENETIC-CONTROL OF PLATELET MONO-AMINE OXIDASE ACTIVITY - STUDIES ON NORMAL FAMILIES

被引：50

作者：

PANDEY, GN ^{[1
]}

DORUS, E ^{[1
]}

SHAUGHNESSY, R ^{[1
]}

DAVIS, JM ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT PSYCHIAT, CHICAGO, IL 60637 USA

来源：

LIFE SCIENCES | 1979年 / 25卷 / 13期

关键词：

D O I：

10.1016/0024-3205(79)90140-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Some groups of psychiatric patients differ from normal individuals with respect to mean platelet monoamine oxidase (MAO) activity. Twin studies indicate that genetic factors contribute to the considerable interindividual variability in the activity of this enzyme. To evaluate the degree of genetic control, we measured platelet MAO activity in 255 normal adult members of 112 families. Between-family variance was significantly greater than within-family variance, as would be expected. Parent-offspring and sibling-sibling correlations indicated that genetic factors control platelet MAO activity to a substantial extent. © 1979.

引用

页码：1173 / 1177

页数：5

共 19 条

[1] BIOCHEMICAL HIGH-RISK PARADIGM - BEHAVIORAL AND FAMILIAL CORRELATES OF LOW PLATELET MONOAMINE-OXIDASE ACTIVITY [J].

BUCHSBAUM, MS ;

COURSEY, RD ;

MURPHY, DL .

SCIENCE, 1976, 194 (4262) :339-341

[2]

EDELSTEIN SB, 1978, J NEUROCHEM, V31, P1247, DOI 10.1111/j.1471-4159.1978.tb06249.x

[3] MONOAMINE-OXIDASE ACTIVITY IN CULTURED HUMAN-SKIN FIBROBLASTS [J].

GROSHONG, R ;

GIBSON, DA ;

BALDESSARINI, RJ .

CLINICA CHIMICA ACTA, 1977, 80 (OCT1) :113-120

[4]

GROSHONG R, 1978, ARCH GEN PSYCHIAT, V35, P1198

[5]

LADURON P, 1978, NEUROTRANSMISSION DI, P113

[6]

LECKMAN JF, 1977, ARCH GEN PSYCHIAT, V34, P601

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8]

MCNEMAR Q, 1962, PSYCHOLOGICAL STATIS

[9]

MELTZER HY, 1974, RES COMMUN CHEM PATH, V7, P419

[10] PLATELET AND PLASMA AMINE OXIDASE ACTIVITY IN 680 NORMALS - SEX AND AGE-DIFFERENCES AND STABILITY OVER TIME [J].

MURPHY, DL ;

WRIGHT, C ;

BUCHSBAUM, M ;

NICHOLS, A ;

COSTA, JL ;

WYATT, RJ .

BIOCHEMICAL MEDICINE, 1976, 16 (03) :254-265

← 1 2 →