ACTIVATION PARAMETERS AND STEREOCHEMISTRY OF AN ANTIBODY-CATALYZED CLAISEN REARRANGEMENT

被引：42

作者：

JACKSON, DY ^{[1
]}

LIANG, MN ^{[1
]}

BARTLETT, PA ^{[1
]}

SCHULTZ, PG ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 02期

关键词：

D O I：

10.1002/anie.199201821

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalysis of the same reaction through different mechanisms was attributed to the diversity of the immune response. The chorismate-prephenate conversion 1 --> 3 can be catalyzed by antibodies raised against an analogue of the transition state 2. These antibodies give rise to a variety of activation parameters for the catalysis. An extremely low activation entropy was found for the antibody 11F1-2E11, which supports the notion that conformational restriction may play an important role in antibody catalysis.

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页码：182 / 183

页数：2

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