DIFFERENTIAL-EFFECTS OF BISMUTH AND SALICYLATE SALTS ON THE ANTIBIOTIC SUSCEPTIBILITY OF PSEUDOMONAS-AERUGINOSA

被引：10

作者：

DOMENICO, P ^{[1
]}

OLEARY, R ^{[1
]}

CUNHA, BA ^{[1
]}

机构：

[1] SUNY STONY BROOK,SCH MED,STONY BROOK,NY 11794

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1992年 / 11卷 / 02期

关键词：

D O I：

10.1007/BF01967072

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

The influence of salicylate or bismuth salts on antibiotic action against Pseudomonas aeruginosa was assessed in broth cultures. Sodium salicylate (2.5 mM) had no significant effect on the activity of any antibiotic tested. In contrast, bismuth compounds (0.5 mM) produced a significant change in the inhibitory activity of several antibiotics against all strains. Bismuth salts reduced imipenem activity by up to 20-fold, enhanced gentamicin or amikacin activity three to five-fold, and enhanced cefpirome or cefepime activity by as much as 10-fold against antibiotic-sensitive and resistant strains. Bismuth salts had little effect on cefoperazone, ceftazidime, or mezlocillin activity. Combining bismuth salts with aminoglycosides or fourth-generation cephalosporin antibiotics may help to combat the growing problem of resistant Pseudomonas aeruoginosa.

引用

页码：170 / 175

页数：6

共 21 条

[1]

POTENTIATION OF SUSCEPTIBILITY TO AMINOGLYCOSIDES BY SALICYLATE IN ESCHERICHIA-COLI [J].