CHARACTERIZATION OF A NOVEL LYMPHOCYTE-T PROTEIN WHICH BINDS TO A SITE RELATED TO STEROID THYROID-HORMONE RECEPTOR RESPONSE ELEMENTS IN THE NEGATIVE REGULATORY SEQUENCE OF THE HUMAN-IMMUNODEFICIENCY-VIRUS LONG TERMINAL REPEAT

被引：17

作者：

ORCHARD, K

LANG, G

COLLINS, M

LATCHMAN, D

机构：

[1] DEPT BIOCHEM,DIV MOLEC PATHOL,MED MOLEC BIOL UNIT,WINDEYER BLDG,CLEVELAND ST,LONDON W1P 6DB,ENGLAND

[2] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

来源：

NUCLEIC ACIDS RESEARCH | 1992年 / 20卷 / 20期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/nar/20.20.5429

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression. The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family. Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex. This protein is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.

引用

页码：5429 / 5434

页数：6

共 26 条

[1] ACTIVATION OF DNA-BINDING ACTIVITY IN AN APPARENTLY CYTOPLASMIC PRECURSOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR [J].