THIOMETHYLATION OF INDOLE AND HALOINDOLE ZINC SALTS

被引：39

作者：

BROWDER, CC ^{[1
]}

MITCHELL, MO ^{[1
]}

SMITH, RL ^{[1
]}

ELSULAYMAN, G ^{[1
]}

机构：

[1] OBERLIN COLL,DEPT CHEM,OBERLIN,OH 44074

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 39期

关键词：

6-BROMO; 6-CHLORO; 5-BROMO; AND; 5-FLUROR-3-(THIOMETHYL)INDOLE; INDOLE; THIOMETHYLATION OF;

D O I：

10.1016/S0040-4039(00)73721-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thiomethylation of indole and haloindoles has been achieved via their zinc salts. This one-pot reaction uses methyl disulfide as electrophile. Isolation of thiomethylated indole products in moderate yields requires the addition of a thiol (e.g., cysteine hydrochloride) during aqueous workup, facilitating the displacement of the thiomethylated product from a water-insoluble zinc salt.

引用

页码：6245 / 6246

页数：2