CLONING AND CHARACTERIZATION OF PENTYLENETETRAZOL-RELATED CDNA, PTZ-17

被引：25

作者：

KAJIWARA, K

SUGAYA, E

KIMURA, M

KATSUKI, M

NAGASAWA, H

YUYAMA, N

TSUDA, T

SUGAYA, A

MOTOKI, M

OOKURA, T

SHIMIZUNISHIKAWA, K

机构：

[1] KANAGAWA DENT COLL,DEPT PHYSIOL,YOKOSUKA,KANAGAWA 238,JAPAN

[2] KEIO UNIV,SCH MED,TSUMURA INST ORIENTAL MED,TOKYO,JAPAN

[3] TOKAI UNIV,SCH MED,DEPT DNA BIOL,ISEHARA,KANAGAWA 25911,JAPAN

[4] KYUSHU UNIV,MED INST BIOREGULAT,DEPT MOLEC & CELLULAR BIOL,HAKATA,FUKUOKA,JAPAN

[5] JOSAI UNIV,FAC PHARMACEUT SCI,SAKADO,SAITAMA 35002,JAPAN

来源：

BRAIN RESEARCH | 1995年 / 671卷 / 01期

关键词：

PENTYLENETETRAZOL; SEIZURE-RELATED GENE; 3 UNTRANSLATED REGION; CALCIUM CURRENT; XENOPUS OOCYTE;

D O I：

10.1016/0006-8993(94)01308-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

cDNAs related to pentylenetetrazol-induced bursting activity in neurons were screened by a differential hybridization method using normal and pentylenetetrazol-treated primary cultured neurons from the cerebral cortex of mice, Twenty clones of candidate cDNA with expression increased or decreased by treatment with pentylenetetrazol were obtained. One of them, PTZ-17, was sequenced. Injection of PTZ-17 derived RNA into Xenopus oocytes showed a large calcium inward current with extracellular application of pentylenetetrazol.

引用

页码：170 / 174

页数：5

共 23 条

[1] PROTAMINE 3'-UNTRANSLATED SEQUENCES REGULATE TEMPORAL TRANSLATIONAL CONTROL AND SUBCELLULAR-LOCALIZATION OF GROWTH-HORMONE IN SPERMATIDS OF TRANSGENIC MICE [J].