EXPLOITING ALTERED GLYCOSYLATION PATTERNS IN CANCER - PROGRESS AND CHALLENGES IN DIAGNOSIS AND THERAPY

被引：94

作者：

TAYLORPAPADIMITRIOU, J ^{[1
]}

EPENETOS, AA ^{[1
]}

机构：

[1] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH,TUMOUR TARGETING LAB,ICRF, CLIN ONCOL UNIT, LONDON W12 0HS, ENGLAND

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 06期

关键词：

D O I：

10.1016/0167-7799(94)90121-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this review, we describe the changes in glycosylation and expression of mucins, in particular, polymorphic epithelial mucin (PEM), the product of the MUC1 gene in tumours and normal tissues. In addition, some of the areas where exploitation of altered glycosylation patterns in tumour mucins can be used for the better understanding of the disease process and be applied for in vivo diagnosis and therapy are addressed.

引用

页码：227 / 233

页数：7

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