CLINICAL AND ULTRASTRUCTURAL CORRELATIONS IN NASAL MUCOCILIARY FUNCTION OBSERVED IN CHILDREN WITH RECURRENT AIRWAYS INFECTIONS

被引：9

作者：

ARMENGOT, M

ESCRIBANO, A

CARDA, C

BASTERRA, J

机构：

[1] UNIV VALENCIA,CLIN HOSP,DEPT PEDIAT,E-46134 FOIOS,SPAIN

[2] VALENCIA MED SCH,DEPT PATHOL,VALENCIA,SPAIN

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 1995年 / 32卷 / 02期

关键词：

AIRWAYS INFECTION; MUCOCILIARY TRANSPORT; CILIARY ULTRASTRUCTURE; PRIMARY CILIARY DYSKINESIA;

D O I：

10.1016/0165-5876(95)01133-V

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

A study was made of 106 children between 1 and 15 years of age (mean 6 years) with recurrent upper and lower airways infections since birth; Nasal mucociliary transport (NMT) velocity was determined in all subjects by the Tc99m-labeled seroalbumin technique. In 42 children, NMT was found to be altered. In this group of patients the technique was repeated in a period of between 1 and 2 years later. In 23 cases (55%) transport had normalized, while in 19 (45%) it remained altered, Recurrent pneumonia and constant rhinorrhea were more frequent in this group. Situs inversus was only detected in 2 of these patients. Pathology showed ciliary ultrastructure, the absence of dynein arms and microtubule alterations. The absence of cilia was observed in some patients, Normal cilia were also encountered in children with persistently altered nasal mucociliary transport.

引用

页码：143 / 151

页数：9

共 31 条

[1]

AFZELIUS BA, 1981, AM J HUM GENET, V33, P852

[2]

AFZELIUS BA, 1986, HOSP PRACT, V21, P73

[3]

AFZELIUS BA, 1983, EUR J RESPIR DIS, V64, P5

[4]

AFZELIUS BA, 1981, AM REV RESPIR DIS, V124, P107

[5] ACUTE AND LONG-TERM AMILORIDE INHALATION IN CYSTIC-FIBROSIS LUNG-DISEASE - A RATIONAL APPROACH TO CYSTIC-FIBROSIS THERAPY [J].

APP, EM ;

KING, M ;

HELFESRIEDER, R ;

KOHLER, D ;

MATTHYS, H .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03) :605-612

[6]

Armengot M, 1993, Acta Otorrinolaringol Esp, V44, P297

[7] NASAL MUCOCILIARY FUNCTION IN THE NORMAL NEWBORN [J].

ARMENGOT, M ;

BASTERRA, J .

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 1991, 22 (02) :109-113

[8]

Armengot M, 1989, Acta Otorrinolaringol Esp, V40, P137

[9]

Armengot M, 1990, Acta Otorrinolaringol Esp, V41, P333

[10]

Armengot M, 1991, Acta Otorrinolaringol Esp, V42, P458

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