METABOLISM OF VALINE AND ISOLEUCINE IN ESCHERICHIA COLI .17. ROLE OF INDUCTION IN DEREPRESSION OF ACETOHYDROXY ACID ISOMEROREDUCTASE

被引：55

作者：

ARFIN, SM

RATZKIN, B

UMBARGER, HE

机构：

[1] Department of Biological Sciences Purdue University Lafayette

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(69)90216-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under conditions that repress the formation of four of the five enzymes required for isoleucine and valine biosynthesis in Escherichia coli and Salmonella typhimurium (growth in the presence of excess isoleucine, valine and leucine), the fifth enzyme, acetohydroxy acid isomeroreductase, is induced by its substrates, acetohydroxybutyrate and acetolactate. Substrate induction appears to be the major if not the only means for regulating the formation of the isomeroreductase in these organisms. The same process seems to occur in Aerobacter aerogenes. © 1969.

引用

页码：902 / &

共 10 条

[1]

ARFIN SM, 1969, J BIOL CHEM, V244, P1118

[2]

BURNS RO, 1968, J BIOL CHEM, V243, P178

[3] REGULATION OF BRANCHED-CHAIN AMINO ACID BIOSYNTHESIS IN SALMONELLA TYPHIMURIUM - ISOLATION OF REGULATORY MUTANTS [J].