LONGITUDINAL URINARY TRACE AMINE EXCRETION IN A HUMAN MALE

The urinary excretion of a β-phenylethylamine (PE), m-tyramine (mTA), p-tyramine (pTA) and tryptamine (TR) in their unconjugated (free) and conjugated (except tryptamine) forms, was examined in a male human subject over a total period of 28 days. The average excretion values were (in μ g per 24 h, mean ± standard error): PE, free 3.19 ± 0.21, conjugated 6.85 ± 0.52; mTA, free 98.0 ± 2.2, conjugated 106.1 ± 18.6; pTA, free 427 ± 12, conjugated 571 ± 142; and TR, free 79.4 ± 2.8. This data, when considered along with other published information, permits the suggestion that probably mTA and pTA in the unconjugated form are exclusively formed endogenously; whether or not this also pertains to PE and TR is less clear. In all cases, the conjugated amines derive from both exogenous and endogenous sources. © 1979.