EFFECTS OF CAPTOPRIL ON BLOOD-PRESSURE AND RESPIRATORY-FUNCTION COMPARED TO VERAPAMIL IN PATIENTS WITH HYPERTENSION AND ASTHMA

被引:8
作者
RISKA, H
SOVIJARVI, ARA
AHONEN, A
SALORINNE, Y
SUNDBERG, S
STENIUSAARNIALA, B
机构
[1] UNIV HELSINKI, CENT HOSP, DEPT PULM MED, SF-00100 HELSINKI 10, FINLAND
[2] LAAKSO AURORA HOSP, HELSINKI, FINLAND
关键词
Asthma; Captopril; Hypertension; Verapamil;
D O I
10.1097/00005344-199001000-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Seventeen adult patients with moderate and stable bronchial asthma and established essential hyper-tension (WHO I or II) were evaluated in a randomized, double-blind, crossover study of the effects of captopril (50-100 mg/day) and verapamil (160-240 mg/day) on blood pressure, orthostatic reactions, respiratory function, and asthmatic symptoms. The effect of both drugs 3n blood pressure was significant. Blood pressure (mean ± f 161/98 mm Hg initially) decreased to a mean of 147/90 and 160/91 mm Hg on captopril and verapamil, respectively, with normal orthostatic changes. There were no significant differences in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), maximal expiratory flow at 50% of FVC (MEF50), or peak expiratory flow (PEF) measurements at the end of each treatment period. The subjective severity of asthma did not change significantly during the trial. No significant cough symptoms were reported on captopril. © 1990 Raven Press, Ltd., New York.
引用
收藏
页码:57 / 61
页数:5
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