ORGANIC ANION TRANSPORT STUDY IN MUTANT RATS WITH AUTOSOMAL RECESSIVE CONJUGATED HYPERBILIRUBINEMIA

被引：34

作者：

KURISU, H

KAMISAKA, K

KOYO, T

YAMASUGE, S

IGARASHI, H

MAEZAWA, H

UESUGI, T

TAGAYA, O

机构：

[1] EIZAI CO LTD,DEPT DRUG SAFETY,GIFU,JAPAN

[2] MEIJI UNIV,KAWASAKI,KANAGAWA 222,JAPAN

来源：

LIFE SCIENCES | 1991年 / 49卷 / 14期

关键词：

D O I：

10.1016/0024-3205(91)90301-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophthalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n=4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities.

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页码：1003 / 1011

页数：9

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