INTERLEUKIN-8 RECEPTOR-MEDIATED CHEMOTAXIS OF NORMAL HUMAN EPIDERMAL-CELLS

被引：98

作者：

MICHEL, G ^{[1
]}

KEMENY, L ^{[1
]}

PETER, RU ^{[1
]}

BEETZ, A ^{[1
]}

RIED, C ^{[1
]}

ARENBERGER, P ^{[1
]}

RUZICKA, T ^{[1
]}

机构：

[1] LMU,DERMATOL KLIN,FRAUENLOBSTR 9-11,W-8000 MUNICH,GERMANY

来源：

FEBS LETTERS | 1992年 / 305卷 / 03期

关键词：

INTERLEUKIN-8; RECEPTOR; IL-8; DIMER; HUMAN KERATINOCYTE;

D O I：

10.1016/0014-5793(92)80677-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normal human keratinocytes show chemotactic behavior towards interleukin-8 (IL-8). Under physiological conditions this cytokine seems to be present in an equilibrium between monomeric and dimeric forms, as indicated by Western blotting data. Radioligand binding studies suggest that keratinocyte chemotaxis is mediated by receptors specific for IL-8 dimers. IL-8 receptor-specific mRNA can be detected in a keratinocyte cell line by polymerase chain reaction.

引用

页码：241 / 243

页数：3

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