TOTAL SYNTHESIS OF MICHELLAMINES A-C - IMPORTANT ANTI-HIV AGENTS

被引：67

作者：

HOYE, TR

CHEN, MZ

MI, L

PRIEST, OP

机构：

[1] Department of Chemistry, University of Minnesota, Minneapolis

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)78487-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michellamines A-C have been prepared by total synthesis in 7 and 16 linear steps from known and commercial materials, respectively. Key steps include i) palladium(0)-mediated biaryl coupling, ii) silver oxide promoted oxidative 1-naphthol coupling to an atropisomeric mixture of cross-ring quinones (indigoids), and iii) simultaneous per-debenzylation/reductive bleaching to the central 2,2'-binaphthol.

引用

页码：8747 / 8750

页数：4

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