COMPLETE SINUS ARREST DURING DILTIAZEM THERAPY - CLINICAL CORRELATES AND EFFICACY OF INTRAVENOUS CALCIUM

被引:15
作者
ANDRIVET, P
BEASLAY, V
KIGER, JP
GNOC, CV
机构
[1] Cardiology-Pnewnology Intensive Care Unit, CMC Bligny
关键词
SINUS DYSFUNCTION; DILITIAZEM;
D O I
10.1093/oxfordjournals.eurheartj.a060502
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The occurrence of severe sinus node dysfunction in 10 patients (three males and seven females; mean age 78·5±3·4, range 57-92 years) receiving oral diltiazem therapy (mean 190±20 mgl24 h, range 90-300) is described Six of them were concomitantly taking amiodarone andlor beta-blocking agents. On admission, seven patients exhibited systemic hypotension and nine complained of asthenia and/or dizziness or drowsiness. ECG findings showed in all a persistent sinus arrest with atrial, junctional or ventricular escape, leading to a mean heart rate of 40·2±3 beats. min-1 (range 257ndash;56). All patients had chronic renal failure on biological tests, with a mean endogenou.s creatinine clearance of 25±3 ml. min-1 (range 12-36). Intravenous calcium hydrochloride (mean 1·4±0·2 g, range 1-2), given in nine patients, rapidly restored stable sinus activity in seven. We suggest that diltiazem should be given cautiously to ageing patients with chronic renalfailure, and confirm the efficacy of intravenous calcium in reversing calcium channel blocker toxicity on sinus node. © 1994 The European Society of Cardiology.
引用
收藏
页码:350 / 354
页数:5
相关论文
共 40 条
[1]   CALCIUM-CHANNEL BLOCKING-AGENTS IN THE TREATMENT OF CARDIOVASCULAR DISORDERS .1. BASIC AND CLINICAL ELECTROPHYSIOLOGIC EFFECTS [J].
ANTMAN, EM ;
STONE, PH ;
MULLER, JE ;
BRAUNWALD, E .
ANNALS OF INTERNAL MEDICINE, 1980, 93 (06) :875-885
[2]   CLASSIFICATION OF SINUS NODE DYSFUNCTION [J].
BASHOUR, TT .
AMERICAN HEART JOURNAL, 1985, 110 (06) :1251-1256
[3]   EFFECT OF DILTIAZEM ON CARDIAC RATE AND RHYTHM AFTER MYOCARDIAL-INFARCTION [J].
BIGGER, JT ;
COROMILAS, J ;
ROLNITZKY, LM ;
FLEISS, JL ;
KLEIGER, RE .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (09) :539-546
[4]   DILTIAZEM - A REAPPRAISAL OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE [J].
BUCKLEY, MMT ;
GRANT, SM ;
GOA, KL ;
MCTAVISH, D ;
SORKIN, EM .
DRUGS, 1990, 39 (05) :757-806
[5]   SPECIFIC PHARMACOLOGY OF CALCIUM IN MYOCARDIUM, CARDIAC-PACEMAKERS, AND VASCULAR SMOOTH-MUSCLE [J].
FLECKENSTEIN, A .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1977, 17 :149-166
[6]   DILTIAZEM AND REINFARCTION IN PATIENTS WITH NON-Q-WAVE MYOCARDIAL-INFARCTION - RESULTS OF A DOUBLE-BLIND, RANDOMIZED, MULTICENTER TRIAL [J].
GIBSON, RS ;
BODEN, WE ;
THEROUX, P ;
STRAUSS, HD ;
PRATT, CM ;
GHEORGHIADE, M ;
CAPONE, RJ ;
CRAWFORD, MH ;
SCHLANT, RC ;
KLEIGER, RE ;
YOUNG, PM ;
SCHECHTMAN, K ;
PERRYMAN, MB ;
ROBERTS, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (07) :423-429
[7]   NIFEDIPINE OVERDOSE [J].
HERRINGTON, DM ;
INSLEY, BM ;
WEINMANN, GG .
AMERICAN JOURNAL OF MEDICINE, 1986, 81 (02) :344-346
[8]   EFFICACY OF DILTIAZEM IN ANGINA ON EFFORT - A MULTI-CENTER TRIAL [J].
HOSSACK, KF ;
POOL, PE ;
STEELE, P ;
CRAWFORD, MH ;
DEMARIA, AN ;
COHEN, LS ;
PORTS, TA .
AMERICAN JOURNAL OF CARDIOLOGY, 1982, 49 (03) :567-572
[9]   NONCARDIOGENIC PULMONARY-EDEMA COMPLICATING MASSIVE DILTIAZEM OVERDOSE [J].
HUMBERT, VH ;
MUNN, NJ ;
HAWKINS, RF .
CHEST, 1991, 99 (01) :258-259
[10]   SINOATRIAL BLOCK INDUCED BY ORAL DILTIAZEM [J].
IMAMURA, T ;
KOIWAYA, Y ;
NAKAMURA, M .
CLINICAL CARDIOLOGY, 1986, 9 (01) :33-34