UTILIZATION OF LIPOSOMES FOR CORRECTION OF THE METABOLIC AND BACTERICIDAL DEFICIENCIES IN CHRONIC GRANULOMATOUS-DISEASE

被引:21
作者
ISMAIL, G
BOXER, LA
BAEHNER, RL
机构
[1] INDIANA UNIV,JAMES WHITCOMB RILEY HOSP CHILDREN,DEPT PEDIAT,DIV PEDIAT HEMATOL ONCOL,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46204
关键词
D O I
10.1203/00006450-197906000-00010
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
IgG-coated liposomes containing glucose oxidase (GO) in order to provide a means of generating H2O2 were prepared. Leukocytes from patients with chronic granulomatous disease (CGD) which are lacking a means of generating H2O2, ingested the IgG-coated liposomes and metabolic oxidative deficiencies of glucose-l-14C oxidation and iodination were normalized. Both of these activities have been shown to depend upon the availability of H2O2 within polymorphonuclear leukocytes. Improvement in the capacity to kill Staphylococcus aureus by chronic granulomatous disease leukocytes were observed under similar conditions. Thus, it is possible to restore the oxidative metabolic capacities to CGD leukocytes by the introduction of glucose oxidase containing liposomes to these cells. © 1979 International Pediatric Research Foundation, Inc.
引用
收藏
页码:769 / 773
页数:5
相关论文
共 29 条