INVITRO ACTIVITY OF SAPERCONAZOLE (R66-905) COMPARED WITH AMPHOTERICIN-B AND ITRACONAZOLE AGAINST ASPERGILLUS SPECIES

Twenty isolates of aspergillus were tested against saperconazole and 16 of these against itraconazole and amphotericin B using a macrodilution broth method. For 18 (90 %) of 20 isolates tested against saperconazole, MICs were ≤3.1 mg/l and for 15 (75 %) of 20 isolates MFCs were ≤3.1 mg/l. For 9 (56 %) of 16 isolates tested against itraconazole, MICs were ≤3.1 mg/l, and for 4 (33 %) of 12 isolates MFCs were ≤3.1 mg/l. For all 16 isolates tested against amphotericin B MICs and MFCs were ≤4.0 mg/l; for 11 of 16 isolates MICs were ≤2.0 mg/l. Saperconazole appears to be highly active against Aspergillus spp. in vitro, with a bimodal distribution of MICs and MFCs. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.