CLOZAPINE HAS SUBMICROMOLAR AFFINITY FOR 5-HT1A RECEPTORS IN HUMAN BRAIN-TISSUE

被引：64

作者：

MASON, SL ^{[1
]}

REYNOLDS, GP ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 2-3期

关键词：

CLOZAPINE; 5-HT1A RECEPTORS; ANTIPSYCHOTIC DRUGS;

D O I：

10.1016/0014-2999(92)90731-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The affinities of a range of antipsychotic drugs at human hippocampal 5-HT1A receptors, defined by specific [H-3]8-OH-DPAT binding, were determined. Clozapine demonstrated the highest affinity; all other antipsychotics studied demonstrated pK(i) values below 6.0. 5-HT1A receptors are found on cortical glutamatergic neurons, a dysfunction of which may occur in schizophrenia. Binding at this site indicates a possible mechanism contributing to the unique efficacy of clozapine in the treatment of some schizophrenic patients.

引用

页码：397 / 398

页数：2

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