DOSAGE EFFECTS OF PULSED STEROID-THERAPY ON SERUM CORTISOL-LEVELS IN ORAL AND MAXILLOFACIAL SURGERY PATIENTS

The purpose of this study was to determine the effects of two dosage regimens of dexamethasone on the serum cortisol levels of a group of patients undergoing major maxillofacial surgical procedures. Analysis of the data demonstrated that the use of dexamethasone, 10 to 20 mg intravenously given every 3 hours intraoperatively and every 4 hours postoperatively over 24 hours, followed by a repository dose of 80 mg of intramuscular methylprednisolone, causes short-term serum cortisol suppression. The maximum depression occurred on postoperative day 3; normal levels were restored by postoperative day 7. Therefore, pulsed therapy can be considered relatively safe when known contraindications have been considered. © 1993, American Association of Oral and Maxillofacial Surgeons. All rights reserved.. All rights reserved.