DIAGNOSIS OF EPSTEIN-BARR VIRUS-INDUCED CENTRAL-NERVOUS-SYSTEM INFECTIONS BY DNA AMPLIFICATION FROM CEREBROSPINAL-FLUID

被引：56

作者：

LANDGREN, M

KYLLERMAN, M

BERGSTROM, T

DOTEVALL, L

LJUNGSTROM, L

RICKSTEN, A

机构：

[1] GOTHENBURG UNIV,DEPT CLIN VIROL,S-41346 GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT PEDIAT 2,GOTHENBURG,SWEDEN

[3] GOTHENBURG UNIV,DEPT INFECT DIS,GOTHENBURG,SWEDEN

[4] CENT HOSP SKOVDE,DEPT INFECT DIS,SKOVDE,SWEDEN

来源：

ANNALS OF NEUROLOGY | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1002/ana.410350522

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A nested polymerase chain reaction was used for the detection of Epstein-Barr virus DNA in 1 patient with encephalitis, and in 1 patient with myelitis. Epstein-Barr virus DNA was detected in cerebrospinal fluid samples obtained at the onset of neurological symptoms in both patients, and serological findings indicated ongoing Epstein-Barr virus infection. In the patient with encephalitis, herpes simplex virus type 1 DNA was transiently detected in the cerebrospinal fluid, while Epstein-Barr virus DNA was still present on day 44 after admittance. Single-photon emission computed tomography in this patient indicated a frontal bilateral hypoperfusion. The diagnostic value of polymerase chain reaction on cerebrospinal fluid and serum samples for Epstein-Barr virus infections of the central nervous system is emphasized.

引用

页码：631 / 635

页数：5

共 15 条

[1] RAPID DIAGNOSIS OF HERPES-SIMPLEX ENCEPHALITIS BY NESTED POLYMERASE CHAIN-REACTION ASSAY OF CEREBROSPINAL-FLUID [J].