ALTERATIONS IN COAGULATION AND FIBRINOLYSIS AFTER SURGERY FOR AORTIC-ANEURYSM

被引：13

作者：

OBA, J

SHIIYA, N

MATSUI, Y

GODA, T

SAKUMA, M

YASUDA, K

机构：

[1] Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, 060, Kita 14-jo

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1995年 / 25卷 / 06期

关键词：

COAGULATION FIBRINOLYSIS; AORTIC ANEURYSM; MOLECULAR MARKERS; CARDIOPULMONARY BYPASS;

D O I：

10.1007/BF00311310

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We investigated the alterations in the coagulation and fibrinolysis systems after aortic aneurysm surgery under cardiopulmonary bypass (CPB) while using newly developed ''molecular markers''. Fibrinogen and antithrombin III (AT-III) decreased after surgery but returned to normal values within three days. The thrombin-antithrombin III complex (TAT) and plasmin-alpha-2-plasmin inhibitor complex (PIC) both showed increased values even preoperatively, which indicated that coagulation and fibrinolysis were activated in some patients with an aortic aneurysm. Both markers maintained a high level for at least 14 days after surgery. The fibrin degradation product (FDP) also showed an increased value before and after surgery. These results apparently showed that coagulation/fibrinolysis had already been activated in some patients and maintained such a state for at least 14 days after surgery. The relation of activated system and postoperative organ dysfunction as well as the means to suppress such activation are also discussed.

引用

页码：532 / 535

页数：4

共 11 条

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