INTRACELLULAR AND INTRAMITOCHONDRIAL DISTRIBUTION OF MALONYL-COA DECARBOXYLASE AND PROPIONYL-COA CARBOXYLASE IN RAT LIVER

1. 1. Malonyl-CoA decarboxylase (EC 4.1.1.9) and propionyl-CoA carboxylase (EC 6.4.1.3) are mitochondrial enzymes. 2. 2. The distribution of malonyl-CoA decarboxylase in fractions obtained by treatment of rat-liver mitochondria with digitonin follows the same pattern as 'matris' enzymes such as malate dehydrogenase and glutamate dehydrogenase. 3. 3. Propionyl-CoA carboxylase is also a 'matrix' enzyme but is much more loosely bound, if at all, to the inner side of the inner membrane. © 1969.