EFFECTS OF BRAIN-SEROTONIN ALTERATIONS ON HYPOTHERMIA PRODUCED BY CHLORPROMAZINE IN RATS

被引：11

作者：

LIN, MT ^{[1
]}

CHERN, YF ^{[1
]}

CHOW, CF ^{[1
]}

LI, YP ^{[1
]}

机构：

[1] NATL DEF MED CTR,DEPT BIOCHEM,TAIPEI,TAIWAN

来源：

PHARMACOLOGY | 1979年 / 18卷 / 03期

关键词：

5,6-Dihydroxytryptamine; Chlorimipramine; Chlorpromazine; Hypothermia; Lilly; 110140; Nialamide; P-Chlorophenylalanine; Raphe neuron; Serotonin; Tryptophan;

D O I：

10.1159/000137241

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ). Depressing the firing of raphe units or decreasing serotonin turnover in the brain with either a serotonin precursor (tryptophan) or the inhibitors of serotonin re-uptake (Lilly 110140 and chlorimipramine) also greatly enhanced the CPZ-induced hypothermia. The data indicate that serotonergic activity in the brain plays a role in the elaboration or modulation of CPZ hypothermia. © 1979 S. Karger AG, Basel.

引用

页码：128 / 135

页数：8

共 24 条

[1] SEROTONIN-CONTAINING NEURONAL PERIKARYA AND TERMINALS - DIFFERENTIAL EFFECTS OF P-CHLOROPHENYLALANINE [J].