ANTAGONISM BY D,1-PROPRANOLOL OF IMIPRAMINE EFFECTS IN MICE

被引：37

作者：

SOUTO, M

FRANCES, H

LECRUBIER, Y

PUECH, AJ

SIMON, P

机构：

[1] Département of Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, F75634 Paris Cedex 13, 91, boulevard de l'Hôpital

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 01期

关键词：

Antidepressants; Psychopharmacological tests; β-Adrenergic receptors; β-Blockers;

D O I：

10.1016/0014-2999(79)90058-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

three agents with known or suspected antidepressant activity, imipramine, salbutamol and dexamphetamine, were active in animal tests predictive of an antidepressant effect in man: antagonism of the yohimbine-induced toxicity. These effects were antagonized by d,1-propranolol, suggesting that the stimulation of β-adrenergic receptors could be a common mechanism underlying their effects. These results agree with the noradrenergic hypothesis of the pathophysiology of affective disorders. © 1979.

引用

页码：105 / 108

页数：4

共 4 条

[1]

FRANCES H, 1978, J PHARMACOL-PARIS, V9, P25

[2] ISOPROTERENOL AND PSYCHOPHARMACOLOGICAL TESTS - ANTAGONISM BY BETA-ADRENERGIC ANTAGONISTS [J].

FRANCES, H ;

SIMON, P .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1978, 10 (03) :211-217

[3]

PUECH AJ, 1978, ADV PHARMACOLOGY THE, V5

[4] EXPERIMENTAL AND CLINICAL-EVIDENCE OF ANTIDEPRESSANT EFFECT OF A BETA-ADRENERGIC STIMULANT [J].

SIMON, P ;

LECRUBIER, Y ;

JOUVENT, R ;

PUECH, AJ ;

ALLILAIRE, JF ;

WIDLOCHER, D .

PSYCHOLOGICAL MEDICINE, 1978, 8 (02) :335-338

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