RELATIONSHIP OF THE CD5 B-CELL TO HUMAN TONSILLAR LYMPHOCYTES THAT EXPRESS AUTOANTIBODY-ASSOCIATED CROSS-REACTIVE IDIOTYPES

被引:81
作者
KIPPS, TJ
DUFFY, SF
机构
[1] at San Diego, La Jolla
关键词
AUTOANTIBODY; CD5; B-CELL; CROSS-REACTIVE IDIOTYPE; V-GENE EXPRESSION;
D O I
10.1172/JCI115239
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We examined human tonsillar B cells for expression of autoantibody heavy-chain or kappa light-chain cross-reactive idio-types (CRIs), respectively defined by murine MAbs G6 or 17.109. We find 17.109 or G6 each specifically binds a subpopulation of B cells, respectively reacting with 3.8 +/- 3% (mean +/- SD) or 2.0 +/- 1.2% of all tonsillar lymphocytes. Cells reactive with both 17.109 and G6 comprise only 0.4 +/- 0.3% of tonsillar lymphocytes. Although each tested specimen had 17.109-positive cells, 2 of 19 tonsils (11%) did not have any G6-reactive cells. We find that CRI-positive cells and CD5 B cells both co-express slgD but fail to bind peanut agglutinin or MAbs specific for CD10, indicating that both cell types reside in the mantle zones of secondary B cell follicles. However, less than half of the B cells bearing one or both of these CRIs express detectable levels of CD5. Nevertheless, we find that G6-reactive lymphocytes constitute a multiclonal population of cells that express homologous heavy chain variable region genes, each rearranged to one of several distinct and apparently nonmutated D and J(H) gene segments. Collectively, these studies indicate that expression of nondiversified autoantibody-encoding variable region genes may not be an exclusive property of B cells that bear detectable levels of the CD5 surface antigen.
引用
收藏
页码:2087 / 2096
页数:10
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