KETOCONAZOLE HEPATOTOXICITY IN A PATIENT TREATED FOR ENVIRONMENTAL ILLNESS AND SYSTEMIC CANDIDIASIS

被引:21
作者
BRUSKO, CS [1 ]
MARTEN, JT [1 ]
机构
[1] ST ELIZABETH HOSP,LAFAYETTE,IN 47903
来源
DICP-THE ANNALS OF PHARMACOTHERAPY | 1991年 / 25卷 / 12期
关键词
D O I
10.1177/106002809102501206
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Environmental illness, a hypothesized disease caused by exposure to substances such as combustion products, pesticides, food additives, and Candida albicans, is discussed. The case of a patient with environmental illness and systemic candidiasis is presented. Following treatment of systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased. One month after discontinuation of ketoconazole, the liver enzyme concentrations decreased; however, over the next five months, liver enzymes and bilirubin increased. The patient developed encephalopathy and eventually was transferred to a medical center for possible liver transplant. A review of the literature pertaining to ketoconazole hepatotoxicity is also presented.
引用
收藏
页码:1321 / 1325
页数:5
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