SEQUENCE-ANALYSIS OF 3 NONSTRUCTURAL PROTEINS OF A PORCINE GROUP-C (COWDEN STRAIN) ROTAVIRUS

被引：12

作者：

BREMONT, M ^{[1
]}

CHABANNEVAUTHEROT, D ^{[1
]}

COHEN, J ^{[1
]}

机构：

[1] INRA,CTR RECH JOUY,VIROL & IMMUNOL MOLEC LAB,DOMAIN VILVERT,F-78350 JOUY EN JOSAS,FRANCE

来源：

ARCHIVES OF VIROLOGY | 1993年 / 130卷 / 1-2期

关键词：

D O I：

10.1007/BF01318998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sequences of three gene products of a group C (Cowden strain) rotavirus are presented and compared with the sequences of the corresponding group A (SA 11) proteins. The degree of similarity for gene 7, 9, and 10 is respectively 34%, 58%, and 45%. Comparison of these 2 viruses allowed to identify several regions well conserved. In the protein coded by Cowden segment 7 (NS 53) only a short cystein and histidine rich region, presenting the zinc finger consensus motif, is common to group A (segment 5) and group C sequences. Conversely the protein coded by segment 9 (NS 35) presented marked homology with group A NS 35. The protein coded by segment 10 (NS 26) is serine rich and presents an accumulation of charged residues near the carboxy terminus, like group A counterpart. This genomic segment presented a single large open reading frame, that contrasts with the group A counterpart for which a second out of phase ORF is used in rotavirus infected MA 104 cells.

引用

页码：85 / 92

页数：8

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