NITRIC-OXIDE PRODUCTION BY MURINE MACROPHAGES IS INHIBITED BY PROLONGED ELEVATION OF CYCLIC-AMP

被引：69

作者：

BULUT, V

SEVERN, A

LIEW, FY

机构：

[1] Department of Immunology, University of Glasgow

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/bbrc.1993.2162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Murine macrophages produce large amounts of nitric oxide (NO) on stimulation by interferon (IFN)-γ and lipopolysaccharide (LPS) or a high concentration of LPS alone. Agents which increase intracellular cAMP levels inhibit cytokine production by macrophages. The effect of increased intracellular cAMP levels on NO production was investigated, using a murine macrophage cell lines, J774. NO production was reduced by prolonged elevation of cAMP, but not by a transient increase. © 1993 Academic Press, Inc.

引用

页码：1134 / 1138

页数：5

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