CLONING AND SEQUENCE OF BONE MORPHOGENETIC PROTEIN-4 CDNA FROM FETAL-RAT CALVARIAL CELL

被引:22
作者
CHEN, D [1 ]
FENG, JQ [1 ]
FENG, M [1 ]
HARRIS, MA [1 ]
MUNDY, GR [1 ]
HARRIS, SE [1 ]
机构
[1] UNIV TEXAS,HLTH SCI CTR,DEPT MED ENDOCRINOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284
关键词
BONE MORPHOGENETIC PROTEIN-4; NUCLEOTIDE SEQUENCE; CDNA; TISSUE SPECIFICITY;
D O I
10.1016/0167-4781(93)90200-W
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A cDNA clone encoding bone mophogenetic protein 4 (BMP 4) has been isolated from a primary fetal rat calvarial cell cDNA library. Sequencing of this clone has revealed a single open reading frame encoding a 408 amino acid protein. Comparison of 5' noncoding exon 1 portion of this cDNA with that of human bone and prostate BMP4 cDNA shows that BMP4 gene expression may possess tissue specificity.
引用
收藏
页码:289 / 292
页数:4
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