REGULATION OF ERYTHROPOIETIN PRODUCTION - NEW INSIGHTS INTO MOLECULAR MECHANISMS OF OXYGEN HOMEOSTASIS

被引：107

作者：

SEMENZA, GL

机构：

[1] JOHNS HOPKINS UNIV, CTR GENET MED, SCH MED, DEPT PEDIAT, BALTIMORE, MD USA

[2] JOHNS HOPKINS UNIV, CTR GENET MED, SCH MED, DEPT MED, BALTIMORE, MD USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1994年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0889-8588(18)30134-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Erythropoietin (EPO) plays a key role in O-2 homeostasis by regulating blood O-2-carrying capacity. EPO is produced primarily in the fetal liver and adult kidney. Expression in liver is controlled by DNA sequences immediately surrounding the gene, whereas expression in kidney requires additional sequences located between 6 and 14 kb 5' to the gene. DNA sequences in the 3' flanking region of the gene mediate hypoxia-inducible EPO transcription by binding several nuclear proteins including hypoxia-inducible factor 1, which is induced by hypoaxia in EPO producing and nonproducing cells and activates transcription of other hypoxia-inducible genes.

引用

页码：863 / +

页数：1

共 87 条

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