CYCLOPHOSPHAMIDE-INDUCED SYNAPTONEMAL COMPLEX DAMAGE DURING MEIOTIC PROPHASE OF FEMALE RATTUS-NORVEGICUS

被引：14

作者：

CUSIDO, L ^{[1
]}

PUJOL, R ^{[1
]}

EGOZCUE, J ^{[1
]}

GARCIA, M ^{[1
]}

机构：

[1] AUTONOMOUS UNIV BARCELONA,INST BIOL FONAMENTAL,E-08193 BARCELONA,SPAIN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 329卷 / 02期

关键词：

CYCLOPHOSPHAMIDE; SYNAPTONEMAL COMPLEX; GENOTOXICITY; MEIOSIS;

D O I：

10.1016/0027-5107(95)00029-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The reproductive system can be especially sensitive to the toxic, carcinogenic or mutagenic effects of alkylating agents. However, since studies of such effects on germ cells are complex, their analysis has been frequently overlooked. In humans, occupational or therapeutic exposure to cyclophosphamide has been associated with male (azoospermia) and female (ovarian failure) sterility or infertility. In this work, we have studied the effect of cyclophosphamide on the formation of the synaptonemal complexes in female rat fetuses. Our results indicate that cyclophosphamide administered at 16 days of gestation, when most germ cells are in a proliferative stage in the female rat, significantly increases the frequency of synaptonemal complex and nucleolar fragmentation in a dose-dependent way.

引用

页码：131 / 141

页数：11

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